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HSP27 inhibitor J2

CAS No. 2133499-85-9

HSP27 inhibitor J2( —— )

Catalog No. M13399 CAS No. 2133499-85-9

HSP27 inhibitor J2 is a small molecule functional inhibitor of Hsp27.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 295 In Stock
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Biological Information

  • Product Name
    HSP27 inhibitor J2
  • Note
    Research use only, not for human use.
  • Brief Description
    HSP27 inhibitor J2 is a small molecule functional inhibitor of Hsp27.
  • Description
    HSP27 inhibitor J2 is a small molecule functional inhibitor of Hsp27, induces significant abnormal HSP27 dimer formation in cancer cells; enhances cancer cell sensitization with cisplatin, cisplatin-induced lung cancer cell growth inhibition in vitro; significantly inhibits immune cell infiltration in lung tissue, attenuates radiation-induced pulmonary inflammation in mice.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Cytoskeleton/Cell Adhesion Molecules
  • Target
    HSP
  • Recptor
    HSP
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2133499-85-9
  • Formula Weight
    264.295
  • Molecular Formula
    C13H12O4S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 20 mg/mL (75.67 mM)
  • SMILES
    O=C1C=C(C)OC2=C1C(O)=CC(OCC3SC3)=C2
  • Chemical Name
    5-hydroxy-2-methyl-7-(thiiran-2-ylmethoxy)-4H-chromen-4-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kim JY, et al. Sci Rep. 2018 Mar 8;8(1):4189. 2. Hwang SY, et al. Eur J Med Chem. 2017 Oct 20;139:892-900.
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